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Post by ghernic on Oct 17, 2012 8:07:41 GMT
hi all, my name is Nick and I have BO for 10 years now. I have no friends, I have nobody actually, I avoid people and society. My body odor varies very much, sometimes fecal body odor, sometimes i smell like garbage, other times is a sour odor. It's a week since i've drowned in the deepest depression i've ever experienced. Every day i think about suicide, i'm completely overwhelmed and desperate. I see no end in sight for this condition, I know now that I'll have to live this nightmare till the end of my life. but it will be much easier for me if i would have someone to talk to, that's why i registered to this forum.
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Post by Sandy on Nov 5, 2012 5:06:27 GMT
Hello. I'm in the same situation as you. I really have no friends although I try and I also avoid society sometimes bcuz of the reactions. I think about suicide a lot but I dont want to go there again, now I have serious health issues and I do believe in hell. Thinking about living with this condition for the rest of my life really makes me feel suicidal as I can barely make it through the day. I've had body odor all my life and fbo now for about 6 years and they have been the worst 6 years of my life. All I can do is be hopeful that it will get better whether it happens or not and keep looking for cures. I'm getting next week for amino acid urine test to test cystine, phenylalanine and methionine and different amino acids which my metabolism of those might cause the bo and I'm getting tested for tmau by the mebo research site. The tests are expensive but when I'm thinking of death its not so bad. I have an appointment with a metabolic geneticist in April and if the amino acid test from the naturopathic doctor shows anything noteworthy ill get tested for the problems of metabolism as well as tmau. I'm saying this as well to give you some information if you need it for testing. Can I ask you where you believe the odor to be coming from and what brought it about. I've tried 100s of things so theres lots of products and although they havent worked for me they have worked for many people. you can try the mebo protocol for tmau with activated charcoal, copper chlorophyllin, vit b2 there are also other metabolic disorders that cause bo like these Odor originating from Metabolic Disorder
a. Trimethylaminuria
Trimethylaminuria also called fish odor syndrome or TMAU is a genetic disease. It is due to abnormal excretion of trimethylamine in the breath, urine, sweat, saliva and vaginal secretions. The odor produced is similar to decaying fish. The smell consists of sulfur compounds, plus nitrogen compounds (amines). The trimethylamine is made by bowel bacteria that break down certain amino acids, carnitine and choline that are in high concentrations in marine fish, egg yolks, certain beans and liver.
b. Maple Syrup Urine Disease
Maple syrup urine disease or MSUD refers to a rare inherited metabolic condition. The first form results from a deficient enzyme (branched-chain alpha-keto acid dehydrogenase, BCKD) necessary for the breakdown of the amino acids leucine, isoleucine, and valine. Without this enzyme, these amino acids build up to toxic levels in the body. If left untreated, this leads to brain damage and progressive nervous system degeneration in infants. Babies that suffer from the mild form have a sugary smell. Adults may have a burned sugar smell to urine. There second form responds well to the vitamin thiamine. It is reported that the patients smell like caramel, maple syrup or have a malty odor.
c. Phenylketunuria
Phenylketunuria or PKU is another inherited metabolic disorder. In this case the body cannot completely break down the protein phenylalanine because it lacks the enzyme phenylalanine hydroxylase. Because of this, phenylalanine builds up in the body’s cells and causes nervous system and brain damage. High levels of phenylalanine leads to increased levels of phenylketones in the blood which are excreted in the urine. The person may present a musty, mousy, wolflike, barny, horsey or stale smell.
d. Multiple Acyl-CoA Dehydrogenase Deficiency
Multiple acyl-CoA dehydrogenase deficiency (MADD) is an inherited fatty acid oxidation disorder (FOD). A person with MADD cannot efficiently breakdown fats and protein into energy. Once the body uses up its first source of energy, blood sugar (glucose), the body becomes weaker because it cannot then make energy from fats. Therefore, people with this disorder must eat on a very regular basis and should not go long without food. The person presents variable body odor of sweaty feet.
e. Isovaleric Acidaemia
Isovaleric acidaemia is a rare genetic condition in which the body is unable to process certain proteins properly. People with this disorder have abnormal levels of an enzyme that helps break down the amino acid leucine, a building block of proteins. It is related to the genetic metabolic disorder Maple syrup syndrome. A symptom of isovaleric acidemia is a odor of cheesy, acrid,sweaty feet. This odor is result of the buildup of isovaleric acid compound.
f. Tyrosinaemia
Tyrosinaemia is an error of metabolism, inherited, in which the body can not effectively break down the amino acid tyrosine, found in most animal and plant proteins. It is an autosomal recessive, that means two copies of an abnormal gene must be present in order for this to develop. There are three types of tyrosinemia, each with distinctive symptoms and caused by the deficiency of a different enzyme. One of the symptoms of Tyrodinaemia type 1 is a odor like cabbage or rancid butter.
g. Diabetes Mellitus
Diabetes Mellitus. Almost all of the food we eat is broken down into glucose (sugar in the blood). Glucose is the main source of fuel for the body and is used by cells for growth and energy. Glucose needs insulin to get into cells. Insulin is a hormone made by the pancreas. In individuals with diabetes, the pancreas may create little or no insulin, or the cells do not react appropriately to the insulin that is produced. Glucose builds up in the blood, and is excreted in the urine. So the body loses its primary source of fuel. Fruity breath is present in people with diabetes.
h. Diabetic Ketoacidosis
Diabetic ketoacidosis. When the level of the blood sugar gets too high, the body creates "ketones" as a by-product of fat digestion. These ketones create blood acidity which causes "acidosis" of the blood. At the same time, the kidneys excrete large amounts of glucose-rich urine, causing dehydration. The patient may have a fruity breath, a sweet taste on the skin, or emanate a distinctive, chemical smell.
i. 3-Methylcrotonylglycinuria
3-Methylcrotonylglycinuria, multiple carboxylase deficiency or 3MCC is another autosomal recessive genetic trait means that this faulty gene usually appears when two carriers have children together and pass it to their offspring. In this case the body is unable to process certain proteins properly. Patients have abnormal levels of an enzyme that helps break down proteins containing the building block (amino acid) called leucine. As a carboxylase enzyme, 3-MCC requires biotin for activity. There are four carboxylases in humans that use biotin and each can be deficient singly or together. If biotin metabolism is defective, functions of all four carboxylases will be low, resulting in Multiple Carboxylase Deficiency. MCC is predominantly located in the inner membrane of the mitochondria. The patient presents an odor like male cat urine.
j. Cystinuria
Cystinuria is an inherited, metabolic disorder. It is characterized by the accumulation of cystine crystals (uroliths, caculi or stones) in the kidneys, ureter and bladder. People with cystinuria cannot properly reabsorb cystine into their bloodstream during the filtering process in the kidneys. Cystine is a amino acid, a building block of proteins. Most of the time, this excess cystine is simply excreted in the urine. But in some cases the cystine cannot stay dissolved and forms crystals. Because cystine is one of the sulfur-containing amino acids, the urine may have a characteristic "rotten egg" odor.
k. Hypermethioninemia
Hypermethioninemia this condition can happen when methionine (amino acid) is not metabolized correctly in the body. Individuals with this condition may experience a fishy, sweety and fruity, rancid butter or boiled cabbage odor. It has been said that tyrosinosis-tyrosinemia is the same as hypermethioninemia.
l. Oast-House Syndrome
Oast-house syndrome also called Smith-Strang diesease is an inherited disease (autosomal recessive) due to malabsorption of methionine and secondary malabsorption of other amino acids. Part of the unabsorbed methionine is converted by colonic bacteria to a-hydroxybutyric acid. The urine has an odor similar to that of dried Celery , yeast or malt, or an oasthouse (a building for drying hops). The patients have white hair, mental retardation among other symptoms.
m. Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia – CAH is a group of inherited disorders which causes an enzyme deficiency (most commonly 21-hydroxylase) resulting in the inability of the adrenal glands to make hormones: cortisol and/or aldosterone. Since the body can't make enough cortisol (and in some cases aldosterone), it stimulates the production of other adrenal hormones that are called androgens. Three main forms of Congenital Adrenal Hyperplasia (CAH) exist: the severe salt-wasting, non-salt wasting forms, and a milder form. The non classical or milder form of CAH can produce body odor during childhood because of the premature puberty
You can find out a lot of these disorders by reading on the mebo website. Have you tried devrom it's supposed to take away the odor from your stool. probiotics have also helped some people.
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Post by anon on Nov 5, 2012 14:55:11 GMT
3 things I would say that make the future more optimistic :
fecal body odor syndrome' is not yet properly classified, so there's no proper treatment (TMAU protocol is for 'fish body odor syndrome'). Once it is properly classified then more suitable treatment will likely be available
gene therapy is around the corner and that will cure many disorders. A few years to go yet but one drug is about to hit the western world market.
Also my impression is that about 10-20% of the public cannot smell me when I smell. So at meetups etc you probably cannot be smelt and vice versa.
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Post by guest13 on Nov 6, 2012 4:39:09 GMT
You may be interested to know that many people with TMAU do not (or do not always) present a fishy body odor. Mine has been described as musty, fishy, burning rubber, cigar smoke, fetal, feet, the list goes on. Needless to say until I found TMAU I was going crazy washing and breaching everything under the sun lol. I did test positive for TMAU.
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