amber
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Posts: 10
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Post by amber on Jun 15, 2012 11:14:35 GMT
Result: Significantly increased trimethylamine (TMA) excretion. The ratio of TMA / TMA-oxide is also significantly increased and possibly indicative of either: - A deficiancy of hepatic TMA oxidation by the flavin-containing mono-oxygenase FMO3 ie. Primary trimethylaminuria - Or a urinary tract infection. ( ) Triethylamine - above normal range - 35.4 umol/mmol creat (2.5 - 10.8) - above high reference limit. TMA-n-Oxide - 56.8 umol/mmol creat (17.0 - 147.0) TMA / TMA-n-Oxide - above normal range - 0.62 (0.05 - 0.21) - above high reference limit Urine creatinine level (XE2qO) 2.2 mmol/L
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Post by anon2 on Jun 15, 2012 12:32:32 GMT
Hi Amber. Perhaps you should try another test to double-check. I have seen results go from 50% to 90% for the same person. Don't think of it as meaning you are bound to smell forever.
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Post by Kreb on Jun 17, 2012 11:32:58 GMT
Amber, let me guess, you are from the UK? Your test results do seem to be positive for primary TMAU. Request a DNA test for piece of mind. They may try and refuse but be persist ant. Result: Significantly increased trimethylamine (TMA) excretion. The ratio of TMA / TMA-oxide is also significantly increased and possibly indicative of either: - A deficiancy of hepatic TMA oxidation by the flavin-containing mono-oxygenase FMO3 ie. Primary trimethylaminuria - Or a urinary tract infection. ( ) Triethylamine - above normal range - 35.4 umol/mmol creat (2.5 - 10.8) - above high reference limit. TMA-n-Oxide - 56.8 umol/mmol creat (17.0 - 147.0) TMA / TMA-n-Oxide - above normal range - 0.62 (0.05 - 0.21) - above high reference limit Urine creatinine level (XE2qO) 2.2 mmol/L
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Post by adrianmcc on Jun 17, 2012 22:50:46 GMT
Your results suggest you have both a bacterial overgrowth in the gut and a deficient enzyme function.
However without a DNA test it is hard to know whether your low oxide ratio is due to a bacterial overgrowth or the genetic disorder.
With your results you should request to be referred to a specialist.
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Post by malory on Jun 22, 2012 10:11:19 GMT
The comments on my initial results were identical to yours Amber but, even so, Dr L would not say I had TMAU type 1. I pushed for a genetic test but the results of that were 'inconclusive' and did not seem to adequately confirm TMAU1 either.
Look at my results on page 2 of 'test results' in this section and you can see how the TMA level changed (lowered) as a result of low choline diet but the odour did not. I do have bacterial overgrowth, as Adrian said, and also faulty FMO3 gene. I am trying to reduce the bacterial overgrowth by not feeding the bacteria with grains (Specific Carbohydrate Diet) but am constantly hungry myself!
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amber
New Member
Posts: 10
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Post by amber on Jun 30, 2012 9:59:47 GMT
Does that mean that bacterial overgrowth does not or cant be treated by antibiotics? I am not sure what to do right at this moment. I had always thought that i had primary tmau as the first incredibly severe sign i had was when i was eight although i didnt realise it at the time. When i got my results i had a bit of a meltdown for a couple of days and i am not sure i have the emotional resolve to put myself through any further tests or unhelpful dotor appointments if it is in the longrun not going to make any difference. i have had this since i was 15 and now unfunnily enough i have turned forty this year and i am finding it impossible to find the willpower to look after my physical self when i am forever stuck with this odour. The extent of my odour / its frequency and people's reactions has been far, far worse since my nerves and stress have increased. i am not at all sure what supplements i should be prob taking or whether any sort of diet would ever help. Food is my last comfort that for some reason i am loathe to forsake - maybe because if that doesn't work then what else could i do. sorry a bit negative as usual but i have never had a positive experience with doctors whether i am not dealing with this or my varying array of other (NOT!) interesting medical difficulties. Does the specific carboyhydrate diet help you?
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Post by junie on Jul 22, 2012 19:39:38 GMT
Has anyone recently taken a TMAU test thru MEBO and gotten results? I had so many questions trying to get and take the test that the person running it seemed to get upset. But now I've been waiting for 5 weeks for the results and have no idea what the status is. I've checked the MEBO site but don't see any notes regarding status, like what patient # they're working on or when I can expect to get results. I know they're "batched" in groups and sent in 20 at a time but where do I fit in?
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Post by malory on Aug 3, 2012 17:01:25 GMT
Amber, from my personal experience I would say that I regret trying antibiotics for my bacterial overgrowth. I will not take them again unless research has been carried out to identify the specific problematic bacteria I have. I will try ozonetherapy and grapefruit seed extract again to try to reduce the bacteria or any alternative treatment but antibiotics will only mess me up more; I think I have fungal candida overgrowth too so the tmau diet is counterproductive for that (as well as being unhealthy if taken to extreme).
I have been doing the no carbohydrate diet for several weeks now with no improvement in odour but i am not going to eat gluten again yet. My odour reduced only for the first day or so of eliminating carbs which perhaps indicates my bacteria feed on carbs but that, once I remove them, they just find something else to eat.
I agree that nerves and stress are crucial in all this. My odour has been getting much worse since my diagnosis in 2010 and my disappointment at the paltry treatment protocol offered. Reducing my tma level does not simply reduce my odour as the medical profession would have us believe.
I understand your reluctance to do restrictive diets; I do ridiculously restrictive diets but, even when i do, I get so frustrated and depressed when they don't work (not to mention worried about the health risks and weight loss) that my odour gets worse.
Still, every one of us is different so, even though your results are similar to mine, I don't want to say that diet or antibiotics won't help you.
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Post by smellykelly on Jul 16, 2013 15:29:36 GMT
Hi All
Just got my fourth test results after being diagnosed 2 years ago now.
TMA 6.2 TMA n Oxide 73.9
TMA/TMA n Oxide 0.08 normal levels.
This is mostly from following the diet alone, as feel antibiotics and other treatments seem to make things worse! But now low in vitamin D levels again. Also, despite a drop from the last part TMA/TMA n Oxide being 0.58, 0.83, & 0.25 in previous tests, I feel like you Malory if anything the odour is worse not better.
So conclude other reasons for odour problem from the liver. Do still have high Candida so I might focus on this now.
SK
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natp1
New Member
Posts: 3
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Post by natp1 on Sept 26, 2013 17:55:01 GMT
Hi all. New Member here.
I was tested back in 2011 for this TMAU as I have been suffering with FBO and BB (the smells are not fishy but are intermittent and comprise differing things at different times. They include: stagnant water, farts, rotten meat, musty unwashed bodily smell. The test was assessed by Sheffield Hospital.
TMA 5.6 TMA -n 49.9 TMA/TMN Oxide 0.11
I read other sources who claim that the oxide figure should be at 95% really which would be 0.05 . I have worked that at 0.11 I my enzyme is processing 89% [49.9 / (49.9+ 5.6) = 0.89 x 100 = 89%]
Whilst they are all within the range for Sheffield's thresholds I believe the significant thing here is not the amount of TMA but rather whether your Liver can deal with the load. Because one thing which sticks out is that those with suspected type 1 (primary) TMAU don't necessarily have high figures compared to others, the crucial factor is whether the FMO3 can oxidise it. I therefore think that all of us who have the odors but don't have big TMA levels for our liver to deal with but are over 0.05 (i.e. below 95% capacity) are probably suffering with TMAU. Because I believe our liver FMO3 gene cannot deal with oxidising some things (it may not be TMA) but something else, but the poor capacity demonstrates this. My pet theory anyway.
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Post by glenn faeroy on Apr 5, 2017 16:58:59 GMT
what are the normal ranges and abnormal ranges in tma,,,,, free tma.... tma-oxide tma-creat levels in the urin and blood tests??? as iam find conflixting levels
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Post by harminder on May 5, 2017 7:29:46 GMT
TMA causes a defect in the normal production of an enzyme named flavin-containing monooxygenase. Trimethylamine builds up and is released in the person's sweat, urine, and breath, giving off a strong fishy odor or strong body odor. You need to consult an urology expert and need to avoid food like egg yolks, legumes, red meats, fish, beans and other foods that contain choline, carnitine, nitrogen, sulfur and lecithin.Take low doses of antibiotics such as neomycin and metronidazole to reduce bacteria growth.Use slightly acidic detergent with a pH between 5.5 and 6.5. Hope, It will be helpful for you.
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